The oncologists at the Ichilov Clinic have a high reputation in the field of diagnosis and treatment of various types of malignant pathologies. An individualized approach to each patient makes the treatment of lymphoblastic B-cell lymphoma in Israel effective and predictable. The therapy program takes into account unique genetic information and the characteristics of the disease, utilizing the latest advancements in immunotherapy, targeted therapy, and other advanced approaches.
At the Ichilov Clinic, special attention is paid not only to the primary disease but also to maintaining the comfort and quality of life of patients and their families. Psychological support courses, physiotherapy, and rehabilitation programs have been developed here. The medical staff speaks English and often knows several other foreign languages, which significantly facilitates communication with international clients. Foreign patients receive comprehensive support, including assistance with organization and accommodation, transfers, and the services of an accompanying translator.
About the Disease
Lymphoblastic B-cell lymphoma is a relatively rare, aggressive oncological disease. The pathology is characterized by malignant changes in B-cell structures – immune system cells responsible for antibody production.
The disease is classified as a form of non-Hodgkin lymphoma but shares many similarities with acute lymphoblastic leukemia, exhibiting characteristics of both lymphoma and leukemia. In both cases, malignancy arises from precursor lymphocytes (lymphoblasts) and can manifest in the lymphatic system, forming tumours, as well as in the bloodstream.
The exact causes of lymphoblastic B-cell lymphoma are unknown. The pathology is associated with hereditary and external factors. It is known that certain genetic changes, such as chromosomal translocations, may play a role in the development of this type of disease.
The most common and characteristic signs of lymphoblastic B-cell lymphoma may include:
- unexplained weight loss
- fever and night sweats
- persistent fatigue and rapid tiredness
- enlargement of lymph nodes without pain
- bones and joint pain
- symptoms of anemia, including pallor and rapid heartbeat
- frequent infections due to immunodeficiency
- symptoms of CNS involvement
- enlargement of the liver or spleen.
Treatment Methods for the Disease
At the Ichilov Medical Center, treatment of B-cell forms of lymphoblastic lymphoma is conducted comprehensively, utilizing the most effective types of interventions.
Intensive Chemotherapy
Four-phase chemotherapy is the cornerstone of treatment for this disease. The process is divided into stages: induction, consolidation, intensification, and maintenance therapy. In each phase, sets of chemotherapy drugs and dosages are individually selected. Chemotherapy regimens typically include several drugs that act synergistically to maximize the destruction of cancer cells.
CNS Prophylactic Therapy
The course of lymphoblastic B-cell lymphoma is associated with the risk of CNS involvement. At the Ichilov Clinic, preventive measures are included in clinical practice to prevent lymphoblasts from penetrating the cerebrospinal fluid or the membranes of the brain. Depending on the characteristics of the disease's progression, intrathecal chemotherapy may be prescribed, with drugs administered directly into the cerebrospinal fluid, or radiation therapy to the brain and spinal cord.
Radiation Therapy
Radiation therapy is used in the treatment of lymphoblastic B-cell lymphoma in cases:
- if the patient has a well-localized tumour,
- for the prevention and treatment of CNS diseases,
- prior to stem cell transplantation.
The Ichilov Clinic is equipped with modern TrueBeam and Lunac linear accelerators, allowing for high precision delivery of high doses of radiation directly to the tumour area, minimizing damage to healthy surrounding tissues and reducing the likelihood of side effects.
Immune and Targeted Therapy
Alongside systemic chemotherapy in the therapeutic methods, immunotherapeutic agents such as monoclonal antibodies targeting the CD20 antigen on the surface of B-cells are often used. These methods can be used alone or in combination therapy, enhancing the effect and increasing the chances of success.
At the Ichilov Clinic, the most current innovative methods that have demonstrated clinical efficacy are applied. New targeted drugs, such as tyrosine kinase inhibitors, promising forms of immunotherapy, and therapy with genetically modified CAR-T cells capable of recognizing and destroying malignant formations, are actively integrated into treatment protocols.
Stem Cell Transplantation
The procedure is performed to restore normal hematopoiesis after high-dose chemotherapy or radiation therapy. Both types of interventions, while destroying malignant cells, also affect healthy bone marrow cells. There are two approaches to stem cell transplantation:
- allogeneic, when healthy cells are taken from a donor,
- autologous, when the patient's own cells are used.
Both approaches aim to restore healthy hematopoiesis and an immune response capable of fighting lymphoma. Stem cell transplantation is used in aggressive or relapsed forms of lymphoma or optionally to achieve long-term remission.
- Stem cell treatment
- Radiation therapy
- Chemotherapy
Methods of Diagnosing the Disease
The Ichilov Clinic conducts a comprehensive set of diagnostic procedures to clarify the stage of the disease, assess etiology, and prognosis. Generally, all diagnostic procedures require three working days.
First Day
The doctor reviews the medical history, collects the anamnesis, assesses the patient's general condition, the presence of enlarged lymph nodes, changes in the size and condition of the liver and spleen, as well as other signs of the disease.
Second Day
- Laboratory blood tests
- Biopsy and histological analysis
- Immunophenotyping
- Molecular studies
- X-ray studies and imaging studies using computer methods
- Lumbar puncture to obtain a sample of cerebrospinal fluid and check for the presence of malignant cells to assess CNS involvement.
Third Day
The results of the studies are analyzed by a team of doctors, including hematologists, oncologists, histologists, radiologists, immunologists, geneticists, radiation oncologists, and transplantologists. The multidisciplinary group confirms the diagnosis, determines the stage of the disease, and selects treatment methods, taking into account the specific characteristics of the patient's progression.
- Biopsy
- X-ray
How Much Does Treatment Cost
The treatment program at the Ichilov Clinic takes into account the individual needs of each patient. The cost is calculated based on the total of all diagnostic and therapeutic procedures. The price is influenced by the volume and complexity of therapy, as well as the need to involve specialists from related disciplines.
Call the phone number listed on the website to find out how much the stay program costs and what it includes. A professional medical consultant will explain how treatment requests are composed and reviewed, where to find ratings and reviews, and information about the clinic's capabilities, departments, and doctors. You can ask any questions through the online chat or feedback forms.
Advantages of Treatment in Israel
- High qualification of doctors and staff
- Modern equipment
- Personalized approach
- Innovative methods of diagnosis and treatment
- Integrative medicine, combining the most effective approaches
Israeli medicine is one of the most progressive and innovative. Numerous scientific studies are conducted here, and promising methods and drugs are implemented that are unavailable in other countries. Modern internet telephony allows for video consultations via Zoom or Skype with leading specialists in the treatment of lymphoblastic lymphomas and obtaining expert assessments relevant to your specific case.