Ihilov Clinic utilizes innovative technologies and therapeutic approaches and is equipped with advanced diagnostic and treatment equipment. A comprehensive set of diagnostic procedures and the most modern and effective treatment protocols for lymphoepithelioid lymphoma in Israel have been developed here.
Specialists at the medical center are leading oncologists and hematologists of world-class, possessing significant experience in treating complex and rare types of oncological hematological diseases. Treatment is monitored by multidisciplinary teams of doctors who coordinate the therapy process comprehensively and effectively. In the fight against lymphoepithelioid lymphoma at Ihilov, the most effective traditional methods, innovative approaches, and the latest developments in pharmacology are combined.
For many years, the clinic has been receiving patients from abroad, providing support in organization, logistics, translations, personal accompaniment, and accommodation for patients' relatives.
About the Disease
Lymphoepithelioid lymphoma (Lennert lymphoma, lymphoepithelioid-cell, lymphoma-like, Lennert lymphoma) is a hematological disease with a unique histological structure. The WHO classifies this condition as an indeterminate peripheral T-cell lymphoma from the Hodgkin lymphoma group. The primary disruption occurs in B-lymphocytes: white blood cells that play a key role in the immune system. The morphological and immunological features of the pathology are due to the dual cellular composition of epithelioid histiocytes and small lymphoid cells.
Currently, the exact causes of lymphoepithelioid lymphoma remain unclear. Scientists consider the role of genetic factors, external influences, and viral infections, including those caused by the Epstein-Barr virus.
The pathology tends to have a more aggressive course compared to other subtypes of Hodgkin lymphoma. Lymphoepithelioid lymphoma affects the lymphatic system, including lymph nodes, and other organs with lymphoid tissue, such as the spleen or thymus.
Signs of the disease may include: enlargement of lymph nodes, fever, night sweats, sudden weight loss, skin itching, and persistent fatigue. Some individuals may experience tenderness in the area of enlarged lymph nodes.
Treatment Methods for the Disease
Treatment of lymphoepithelioid lymphoma is a combined approach, where each method is selected individually based on the stage, overall condition, and response to treatment. Each case of the disease is unique and requires adaptation of treatment options to the specific needs of the patient.
Chemotherapy
Chemotherapy is the basic method that can be used alone or in combination with other treatment strategies. Modern Israeli medicine offers wide opportunities for combating the disease. There are various chemotherapy treatment programs, among which the most common are the ABVD and BEACOPP regimens. Combinations of medications, their dosages, and specific administration schemes are tailored individually for each patient. From the first day of therapy, doctors at Ihilov monitor how effectively the body responds to treatment and promptly adjust the program.
Immunotherapy
Immunotherapeutic treatment uses bioactive substances. The goal of therapy is to awaken the natural defense mechanism to fight transformed cells. One of the effective approaches to treating lymphoepithelioid lymphoma is therapy with monoclonal antibodies. These are laboratory-developed antibodies targeting CD20. They specifically affect certain protein structures and oncological antigens without damaging healthy cells.
Radiotherapy
Radiation is used in cases of localized forms of lymphoepithelioid lymphoma to destroy tumor cells in limited areas. Radiation therapy is applied as an independent treatment method or in combination with chemotherapy to enhance overall effectiveness.
The Ihilov medical center is equipped with advanced TrueBeam and Lunac linear accelerators. These are the latest generation of radiological equipment, providing precision targeting of neoplasms considering the shape and boundaries of the tumor. With IMRT technology, it is possible to adjust the radiation power during the treatment session, increasing the dosage directly on the affected areas and minimizing it for healthy tissues. The use of computed tomography and MRI allows specialists to continuously monitor the dynamics of changes in the boundaries and position of the tumor, timely adjusting the radiation impact plan.
Visceral Therapy
One of the characteristic complications of lymphoepithelioid lymphoma is its spread beyond the lymphatic system. In cases of internal organs affected by malignant cells, visceral therapy is advisable. The goals of the procedures are:
- to reduce the size of the tumor in the organ,
- to prevent further spread,
- to improve quality of life and overall well-being.
Therapeutic measures include a combination of anti-tumor agents, biologically active substances, and monoclonal antibodies, as well as targeted radiation therapy. The essence of visceral therapy is the simultaneous impact on the primary source of the disease in the lymphatic system and the affected internal organs. This approach increases the chances of a favorable prognosis and prevents complications related to the dysfunction of the affected organs.
Stem Cell Transplantation
Autologous stem cell transplantation may be an option for individuals suffering from recurrent or treatment-resistant lymphoma. This method involves returning the patient's own stem cells, which have been previously collected, processed, and frozen. Stem cell transplantation is recommended after intensive chemotherapy or when there are risks of disease recurrence.
- Stem cell treatment
- Radiotherapy
- Chemotherapy
Diagnostic Methods for the Disease
This rare pathology is characterized by histopathological signs of granulomas, very similar to those observed in other diseases. The Ihilov medical center has developed special techniques that allow for the accurate diagnosis of lymphoepithelioid lymphoma, excluding diseases with similar morphology, such as Hodgkin's disease, angioimmunoblastic adenopathy, and sarcoidosis. A phased integrated approach is used to clarify the diagnosis.
First Day
The doctor collects information about the patient's complaints, reviews the medical history, and prepares the anamnesis. A thorough physical examination is then conducted.
Second Day
- Blood tests
- Lymph node biopsy
- Immunophenotyping to determine the type of lymphoma
- Molecular genetic tests, including polymerase chain reaction and gene sequencing
- Computer diagnostic procedures, such as CT, PET, and MRI
Third Day
A multidisciplinary team confirms the diagnosis based on the analysis of symptoms, histology data, immunophenotyping information, molecular research results, and imaging. This approach allows for a comprehensive assessment of the patient's health status, determination of the disease stage, and selection of the most appropriate treatment scheme.
- Biopsy
- Computed Tomography
- Magnetic Resonance Imaging (MRI)
- Diagnosis — PET CT
How Much Does Treatment Cost
At Ihilov Clinic, each treatment course is created considering individual characteristics. The payment for medical services depends on the volume and complexity of the diagnostic studies conducted and the chosen treatment methods. The price is influenced by the need for specific procedures or consultations with narrow specialists.
For detailed information, please contact us by phone, through the online chat on the website, or via the feedback form. The medical coordinator will explain in detail the factors affecting the cost and the services included in the basic package. You will learn about the clinic's equipment, the specialization of departments, the level of qualifications, the experience of specialists, their reputation, and patient reviews.
Advantages of Treatment at Ihilov Clinic
- Treatment protocols based on modern medical innovations
- Qualified specialists working in multidisciplinary teams
- Individual approach to each patient
- Comprehensive medical strategies
- Experience in treating patients from different countries
Israel is renowned for its successes in treating diseases of the lymphatic system of oncological nature. Modern communication means allow for prompt consultations with a doctor specializing in this field. Request a remote consultation via Zoom or Skype, and the doctor, based on available conclusions and research results, will assess your condition and suggest optimal further steps.