Ihilov Clinic is equipped with modern diagnostic and treatment equipment of the latest generation. Here, high-precision diagnostics are performed, and the most advanced and effective methods for treating Lennert's lymphoma in Israel are applied. The medical center employs oncologists and hematologists recognized globally and having successful experience in treating complex and rare forms of oncological hematological pathologies.
Treatment is conducted by multidisciplinary teams that comprehensively and effectively manage the therapy process. The clinic combines proven methods, innovative approaches, and the latest pharmacological developments.
Ihilov has been accepting patients from other countries for many years, providing assistance in organization, logistics, translation, personal accompaniment, and accommodation for patients' families.
About the disease
Lennert's lymphoma (lymphoepithelioid, lymphoepithelioid-cell, lymphoma-like, Lennert lymphoma) is a rare pathology with a unique histological structure. According to the WHO classification, it belongs to the general category of Hodgkin's lymphomas – unspecified peripheral T-cell lymphomas. However, the pathology actually arises from B-lymphocytes – white blood cells involved in the immune response. The features of morphology and immune response are due to a two-component cellular composition of epithelioid histiocytes and small lymphoid cells.
The exact causes of Lennert's lymphoma have not yet been established. Researchers suggest the possibility of the influence of genetic and external factors, viral infections such as Epstein-Barr virus.
Lennert's lymphoma may progress more aggressively than other subtypes of Hodgkin's lymphoma. Symptoms of the pathology may include swollen lymph nodes, fever, night sweats, unintentional weight loss, skin itching, and fatigue. Some patients experience tenderness in the enlarged lymph nodes.
Treatment methods for the disease
Treatment of Lennert's lymphoma is a complex process that requires an individualized approach, depending on the stage of the disease, the overall condition of the patient, and the response to therapy. Each case of Lennert's lymphoma is unique, and the treatment approach is adapted to the specific needs of the patient.
Chemotherapy
Chemotherapy is the cornerstone of Lennert's lymphoma treatment. It can be used as monotherapy or in combination regimens. The most common chemotherapy regimens are ABVD and BEACOPP. The combination of drugs, dosage, and regimen depend on many factors, including the stage of the disease, response, and health status of the patient.
Immunotherapy
Immunotherapy uses biological agents to stimulate the body's own defense mechanisms to fight cancer. Monoclonal antibody therapy has shown effectiveness in treating Lennert's lymphoma. Laboratory-created antibodies against CD20 specifically target certain parameters of protein molecules and the cancer-associated antigen, without affecting healthy cells.
Radiotherapy
Radiotherapy may be used in cases of localized Lennert's lymphoma to destroy cancer cells in specific areas. This approach is most appropriate when there are specific sites where the disease manifests most significantly. Radiotherapy can be used as a standalone treatment method or in combination with chemotherapy to increase effectiveness.
At Ihilov Clinic, modern high-precision linear accelerators TrueBeam and Lunac are used. This state-of-the-art radiotherapy equipment allows for precise targeting of the tumour according to its shape and size. The IMRT mode changes the intensity of the beam during the current session, delivering high doses of radiation directly to the tumour areas while reducing the dose that reaches surrounding healthy tissues. CT and MRI functions allow doctors to monitor the position and size of the tumour in real-time, adapting the radiotherapy plan.
Visceral therapy
Lennert's lymphoma can spread beyond the lymphatic system, affecting internal organs and causing a variety of symptoms and complications. In cases of internal organ involvement, visceral therapy may be required. This is a set of measures aimed at treating lesions of internal organs caused by the tumour. The goals of therapy are:
- to reduce the tumour mass in the affected internal organ,
- to prevent the spread of the disease to other parts of the body,
- to improve overall condition and quality of life.
Visceral therapy methods include a combination of anti-tumour drugs, biological agents, and monoclonal antibodies, as well as targeted radiotherapy.
The importance of visceral therapy lies in its comprehensive impact not only on the primary focus of the disease in the lymphatic system but also on the affected internal organs. This approach increases the chances of a successful prognosis, helps manage symptoms, and prevents complications related to the dysfunction of the affected organs.
Autologous stem cell transplantation
For patients with relapsed or refractory Lennert's lymphoma, autologous stem cell transplantation may be considered. This procedure involves returning the patient's own previously collected, processed, and preserved stem cells. Stem cell transplantation is most appropriate after high-intensity chemotherapy, in cases of risks or recurrence.
- Bone marrow transplantation in Israel
- Radiotherapy
- Chemotherapy
Diagnostic methods for the disease
This rare disease is characterized by granulomatous-type proliferation, similar to manifestations of other pathologies. At Ihilov Clinic, protocols have been developed to accurately identify Lennert's lymphoma, excluding morphologically similar Hodgkin's disease, angioimmunoblastic adenopathy, and sarcoid granuloma.
The variety of manifestations and cross-morphological characteristics require a comprehensive approach to diagnostics, which is conducted in stages and usually takes three days.
First day
The doctor collects complaints, reviews the patient's medical history, and compiles an anamnesis. A complete physical examination is conducted.
Second day
- Blood tests
- Lymph node biopsy
- Immunophenotyping for accurate identification of the type of lymphoma
- Molecular genetic studies: polymerase chain reaction, sequencing
- Imaging tests: CT, PET, MRI
Third day
At Ihilov Clinic, the diagnosis is confirmed by a multidisciplinary group analyzing symptoms and results from histology, immunophenotyping, molecular tests, and imaging. A collegial approach allows for a comprehensive assessment of manifestations, establishing the stage of the disease, and selecting the most effective treatment strategy.
- Biopsy
- Computed Tomography
- Magnetic Resonance Imaging (MRI)
- Diagnostics — PET CT
How much does treatment cost
Each treatment program at Ihilov is developed individually. The cost of services is based on the volume and complexity of diagnostic procedures, treatment methods, and the need for specialized manipulations or expert consultations.
Call the phone number, write in the online chat on our website, or use the feedback form. A healthcare coordinator will provide detailed information about what affects the price and what is included in the treatment program. Get up-to-date information about the medical equipment available at the clinic, the specialization of departments, the qualifications and experience of doctors, their reputation, and patient reviews.
Advantagesof treatment at Ihilov Clinic
- Modern medical technologies;
- Highly professional specialists working in teams;
- Personalized approach to each patient;
- Application of integrative medical approaches, the latest treatment methods and drugs validated by clinical trials;
- Experience in organizing treatment for international patients.
Israel is known for its achievements in treating oncological hematological pathologies of the lymphatic system. Today, from anywhere in the world, you can consult with a leading expert in this field using video communication via Zoom or Skype. Order a remote consultation, and the doctor, based on the available conclusions and test results, will assess the condition and suggest options for further action.